Rousselot, a Darling Ingredients global company and the leading global producer of gelatin and collagen peptides, has released the findings of a new clinical study on the effects of Peptan® collagen peptides on skin beauty and hair strength. Adding further evidence to Peptan’s strong scientific portfolio, the study revealed that the oral supplementation with Peptan collagen peptides significantly contributes to improving the overall appearance of skin and hair in an ethnically diverse population.
Promoting smooth-looking skin with collagen peptides
The randomized, double-blind, placebo-controlled clinical research was conducted with 60 healthy Brazilian women, aged 45 to 60 years. During a set period of 90 days, a group of 30 participants received a 5g daily dose of Peptan collagen peptides from bovine origin (Peptan B) while the remaining subjects consumed a placebo control. Parameters of skin characteristics in the region of the cheeks, around the nose, eyes, mouth, as well as hair strength, were evaluated at baseline prior to supplementation and again 45 and 90 days after supplementation with high-end, state-of-the-art techniques.
Results showed significant improvements in the overall appearance of the skin, characterized by a decrease in periorbital wrinkles by 13% and nasolabial wrinkles by 10% and a reduction of the visibility of pores in the region of the cheekbones in 57% of the Peptan-supplemented participants. At the basis of those observations was a clear increase of the density of the dermis, which contains the strength-providing collagen layer of the skin, following Peptan supplementation.
Bringing new scientific evidence for hair strength
While collagen is known for promoting stronger and healthier hair, there has been no scientific assessment of these beauty benefits until now. This new study evaluated the characteristics of hair using a texturometer before and after Peptan supplementation clearly demonstrating an increase of the mechanical strength of the hair by 13% in the Peptan group compared to the placebo group. Mechanical strength is linked to improved properties of the hair cortex, which can be especially beneficial for aging hair.
Broadening Peptan’s Scientific Portfolio for Skin Beauty
The new scientific evidence broadens the understanding of benefits delivered by Peptan collagen peptide supplementation for beauty in several ways. Previous clinical reports have demonstrated that oral Peptan collagen peptide supplements can reduce the signs of skin aging by improving skin hydration,,,, elasticity3,4,5 and dermal collagen density. The study provides further evidence on the efficacy of Peptan collagen peptides from bovine origin, at a lower dose. Conducted in a Brazilian population of mixed skin and hair types, this also brings additional proof that Peptan is efficacious across populations of different ethnical backgrounds2,5,,, adding to the previous evidence obtained from trials in Caucasian and Asian populations.
Peptan’s range of collagen peptides are safe, bioactive and developed through an optimized hydrolyzation process, which makes collagen peptides highly bioavailable, and provide targeted benefits in the key connective tissues of the human body. A leading global brand of choice, Peptan collagen peptides are widely used in nutricosmetic applications and continue to grow in popularity among manufacturers looking to differentiate their products, thanks to the wealth of vital information supplied by Rousselot’s extensive scientific research.
To find out more about the latest science on Peptan collagen peptides, download Peptan’s white paper ‘Collagen peptides for promoting skin beauty and hair health’: https://www.peptan.com/about-peptan/downloads/collagen-peptides-for-skin-beauty-and-hair-health
References Rousselot unpublished study  Asserin, J et al. The effect or oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J of Cosmetic Dermatol 2015; 0 – 1-11  Matsumoto H et al Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies and Medicine 2006; 7 (4): 386-390  Ohara H et al Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion. Food Science and Technology Research 2009; 56 (3): 137-145  Inoue N et al Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomized, double-blind, placebo-controlled clinical study. J Sci Food Agric 2016; 96(12):4077-81  Chung JH et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 2001; 117:1218-24.
PUBLISHED IN THE OPEN NUTRACEUTICALS JOURNAL
An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies in The Open Nutraceuticals Journal, february 2015.
The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials
- Jérome Asserin PhD, Elian Lati PhD, Toshiaki Shioya B.Eng., Janne Prawitt PhD
First published: 12 September 2015 Full publication history
Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. Our aim was to investigate the effect of oral supplementation with specific collagen peptides on skin hydration and the dermal collagen network in a clinical setting.
Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo.
Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Both effects persisted after 12 weeks. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects.
The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging.
With a unique amino acid profile, ZZAZEN collagen peptides contain high levels of the amino acids glycine, hydroxyproline, proline, alanine and arginine providing specific nutritional benefits not found in other protein sources. In short, ZZAZEN offers multiple benefits linked to muscles, athlete performance and connective tissue support. This makes ZZAZEN great as sports nutrition.
ZZAZEN deliver numerous health and nutritional benefits to athletes both during and after exercise. The list of health benefits for sports nutrition:
- Aiding muscular contraction
- Muscle restoration
- Provide energy for performance
- Protecting joints and connective tissues
- Weight management
Aiding muscular contraction
Muscular function is dependent on the energy produced by the breakdown of a compound called adenosine triphosphate (ATP) in cells.
Creatine is a molecule consisting of three amino acids – glycine, arginine and methionine – that can aid muscular contraction during periods of high intensity exercise and also helps to replace depleted ATP levels. ZZAZEN, which consists of 20% glycine and 8% arginine, can support the synthesis of creatine in the body to improve performance during short bursts of exercise and help athletes to increase their body mass.
During and after long periods of exercise, protein loss can occur in the muscles as their structural integrity is compromised by oxidation, membrane microlesions and inflammatory reactions. A high protein sports nutrition diet just after exercise may enhance muscle anabolism, replacing lost proteins and helping to maintain and restore the protein content of the muscles while also reducing recovery time.
Providing energy for performance
Oral arginine supplements may also have a beneficial effect on athletic performance, even at a low dose. A daily dose of 10g of ZZAZEN produces the recommended dose of arginine per day. A study showed that by ingesting 1g supplements of arginine and ornithine taken five days per week for five weeks for sports nutrition can increase strength. Studies suggest that arginine stimulates the release of growth hormone from the pituitary gland, which may explain performance improvement.
Supporting connective tissues and preventing injuries
ZZAZEN can support joint health by regenerating cartilage and reducing joint inflammation, as demonstrated in a recent in-vivo study. ZZAZEN can increase the production of cartilage matrix, aggrecan and type II collagen. An in vivo study also demonstrated a significant increase in collagen fibril diameter of the Achilles tendon after collagen peptides supplementation for 8 weeks.
Collagen peptides may help protect the joint matrix and help to reduce joint discomfort. A clinical study has shown that ZZAZEN can help reduce joint stiffness.
In a large-scale study of different categories of athletes, those taking a mix of collagen peptides, BCAA and arginine over a period of two years experienced a decreased tendon, ligament, joint and muscle injury rate. A smaller, placebo controlled study confirmed that consuming a collagen supplement with vitamin C, followed by a burst of intensive exercise, can help build ligaments, tendons and bones, and likely play a beneficial role in injury prevention and tissue repair. Additional clinical evidence for injury prevention are reported on athletes by Baar, 2015, and Ribas-Fernandez, 1998.
Weight management with sports nutrition
Known to be among the most satiating macronutrients, proteins can prevent cravings and help people reach their fitness and weight goals. ZZAZEN collagen peptides are particularly renowned for their ability to help individuals lose or maintain weight when incorporated in weight management formulations.
An in vivo study conducted in 2006 by the Laboratory of Physiology and Ingestive Behavior, INRA-AgroParis Tech (Paris, France), showed that ZZAZEN is more effective than a standard dairy protein in weight management.
A 2009 study demonstrated the improved satiating effect of collagen peptides on humans, in comparison to other proteins. The study showed that collagen peptides – taken alone or supplemented with tryptophan – are 30 to 50% more satiating than casein, soy or whey.
Main source of ZZAZEN is Peptan, worlds leader in collagen peptides.